Polygonum barbatum, an herbal plant which is used in traditional medicine for the management of gastric ulcers. Therefore, the purpose of the study was to investigate the antiulcerogenic effect of Aqueous (AEPB) and Hydroalcoholic (HEPB) extracts of Polygonum barbatum in the dose of 100 and 200mg/kg, b.w. on pyloric ligation (PL), HCl/ethanol (EtOH) and indomethacin (IND) induced gastric ulcer models in Sprague dawley rats. Omeprazole (OMP) (10mg/kg b.w.) was used as a standard drug for all the above models. The standard drug and herbal extracts were given orally to the animals. The HEPB at 200mg/kg significantly inhibited the gastric lesions induced by PL (75.7%), EtOH (68.6%) and IND (45.1%), respectively. Hence HEPB at higher dose produce significant anti-ulcerogenic effect.
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